CSE1L, chromosome segregation 1 like, 1434

N. diseases: 163; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0339143
Disease: Thyroid associated opthalmopathies
Thyroid associated opthalmopathies
0.030 Biomarker disease BEFREE When the analysis was restricted to untreated GO patients, a correlation was found between CAS and both total (p = 0.04) and LDL-cholesterol (p = 0.03), after adjustment for GO duration. 29336220 2018
CUI: C0022602
Disease: Actinic keratosis
Actinic keratosis
0.010 AlteredExpression disease BEFREE We used the CAS 200 image analysis system to measure nuclear morphometric parameters, p53 expression, and proliferation markers in actinic keratosis (AK), sun-exposed, and normal skin in 51 patients. 15598753 2004
CUI: C0751072
Disease: Frontotemporal Lobar Degeneration
Frontotemporal Lobar Degeneration
0.010 Biomarker disease BEFREE We propose that cellular apoptosis susceptibility protein associated defective nuclear transport may play a mechanistic role in the pathogenesis of the TDP-43 positive frontotemporal lobar degeneration. 20472655 2010
CUI: C3811918
Disease: GRN-related frontotemporal dementia
GRN-related frontotemporal dementia
0.010 Biomarker disease BEFREE We propose that cellular apoptosis susceptibility protein associated defective nuclear transport may play a mechanistic role in the pathogenesis of the TDP-43 positive frontotemporal lobar degeneration. 20472655 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.060 Biomarker group BEFREE We have performed this emergency operation in 2 patients with acute early stroke after CAS. 28887238 2018
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus
0.010 Biomarker disease BEFREE We found minimal to absent CAS/CSE1L in all BE tissue samples; however, CAS/CSE1L was upregulated in 60% of LGD and overexpressed in HGD and ADC. 27941559 2018
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.010 AlteredExpression group BEFREE We found minimal to absent CAS/CSE1L in all BE tissue samples; however, CAS/CSE1L was upregulated in 60% of LGD and overexpressed in HGD and ADC. 27941559 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.080 Biomarker group BEFREE We determined the DNA ploidy value of each individual focus of cancer in radical prostatectomy specimens using nuclear image analysis (CAS 200 system). 8158775 1994
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.070 Biomarker group BEFREE We determined the DNA ploidy value of each individual focus of cancer in radical prostatectomy specimens using nuclear image analysis (CAS 200 system). 8158775 1994
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.010 Biomarker group BEFREE We demonstrate a high-grade molecular homology between canine and human CAS, and show that enrichment of upregulated canine CAS genes strongly correlates with the enrichment of an independently derived human stromal signature in the TCGA breast tumour dataset. 31308057 2019
CUI: C1527349
Disease: Ductal Breast Carcinoma
Ductal Breast Carcinoma
0.010 GeneticVariation disease BEFREE We analyzed 25 cases of archived, paraffin-embedded breast carcinoma (ductal) for Feulgen stain DNA analysis and MIB-1 immunohistochemistry using the CAS 200 Image Cytometer. 9142183 1997
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.020 AlteredExpression disease BEFREE Using specific antibodies for the cellular apoptosis susceptibility (CAS) gene, caspase-3, Bcl-2, and Bax, we examined the protein expression in 89 endometrial carcinomas and in 56 samples of nonneoplastic adjacent endometrium for comparison. 11603220 2001
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.080 Biomarker disease BEFREE Two STs; ST26 (CAS_Delhi) and ST1 (Beijing) represented 36.1% of the total M. tuberculosis population in eastern Uttar Pradesh, North India. 18372222 2008
CUI: C0030193
Disease: Pain
Pain
0.020 Biomarker phenotype BEFREE Two ERP experiments were designed to explore the effect of predictability (Exp1) and probability (Exp2) on the perception of others' pain, respectively. 30081120 2018
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases
0.010 Biomarker group BEFREE To evaluate the impact of baseline CKD in TAVR patients only, all patients undergoing an attempted TAVR implant in the US Pivotal Trial and CAS were stratified by baseline eGFR into none/mild, moderate, and severe CKD. 30341970 2019
CUI: C0553694
Disease: Oropharyngeal disorders
Oropharyngeal disorders
0.010 Biomarker group BEFREE To address the genotoxicity of in vivo methyl bromide (CAS 74-83-9) exposure in humans, we collected blood and oropharyngeal cells as part of a cross-sectional morbidity study of methyl bromide-exposed fumigation workers and their referents. 9733941 1998
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Thus, CAS/Crk assembly serves as a "molecular switch" for the induction of cell migration and appears to contribute to the invasive property of tumors. 9472046 1998
CUI: C0409959
Disease: Osteoarthritis, Knee
Osteoarthritis, Knee
0.010 Biomarker disease BEFREE This prospective cohort study aimed to evaluate the outcome and survivorship of the native patella in computer-assisted TKA (CAS TKA) implanted for primary knee osteoarthritis, and to determine the predictive factors of secondary patellar resurfacing (SPR). 28889222 2018
CUI: C0558066
Disease: Intrusive thoughts
Intrusive thoughts
0.010 Biomarker disease BEFREE This longitudinal study mapped distinct trajectories of Fear of cancer recurrence (FCR) over 12 months among patients with breast (BC) or colorectal (CRC) cancer, and examined if metacognition, indirectly via attentional bias, intrusive thoughts and avoidance (hallmarks of cognitive attentional syndrome; CAS) predicted FCR trajectory membership. 31663187 2020
CUI: C0233705
Disease: Cancerophobia
Cancerophobia
0.010 GeneticVariation disease BEFREE This longitudinal study mapped distinct trajectories of Fear of cancer recurrence (FCR) over 12 months among patients with breast (BC) or colorectal (CRC) cancer, and examined if metacognition, indirectly via attentional bias, intrusive thoughts and avoidance (hallmarks of cognitive attentional syndrome; CAS) predicted FCR trajectory membership. 31663187 2020
CUI: C0221269
Disease: Pseudolymphoma
Pseudolymphoma
0.010 Biomarker disease BEFREE Thirty smears of histologically proven low grade NHL (10 follicular lymphomas of centroblastic-centrocytic type, 10 lympho-plasmocytoid immunocytomas, 10 chronic lymphocytic leukemias) and 15 smears of RLH were stained with Feulgen and examined by image analysis (CAS 200, Becton Dickinson). 9673378 1998
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.030 Biomarker group BEFREE These results suggest that EXP1 and/or EXP2/Cyclin D1 may play an important role in the progression of human esophageal carcinomas. 8250909 1993
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 Biomarker disease BEFREE These included downregulation of CALMODULIN:, which is critical to T-cell activation, and of cellular apoptosis susceptibility protein, which may mediate resistance to apoptosis in RA. 11181651 2001
CUI: C0750927
Disease: Apraxia, Developmental Verbal
Apraxia, Developmental Verbal
0.060 GeneticVariation disease BEFREE These are the first reported cases with well-characterized CAS in the 16p11.2 syndrome literature and the first report of this microdeletion in CAS genetics research. 22909774 2013
CUI: C0015300
Disease: Exophthalmos
Exophthalmos
0.010 Biomarker disease BEFREE There were significant differences in the case of exophthalmia (P=0.002), CAS (P=0.006), and Palpebral fissure (P=0.029) between the first visit and 6 months after treatment. 31345156 2020